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Start by picking a good injection site

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The participants weighing an average of 96.4 kg lost 4.5 kg with a 14 mg dose of oral semaglutide, 7.0 kg with 25 mg and 9.2 with 50 mg

Additionally, semaglutide influences the vagus nerve , which communicates between the gut and brain, further contributing to gastrointestinal symptoms

Dysaesthesia has been reported in some clinical trials of semaglutide, including the STEP UP T2D trial of subcutaneous semaglutide, results of which showed that the adverse effect was more common with 7.2 mg doses (n=58 [18.9%] of 307) compared with 2.4 mg doses (n=five [4.9%] of 103)